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Validity of Serum Cystatin c for Predicting Obesity Nephropathy
Zahra Asefy2,*, Masoud Khodaei3 and Vida Hashemi1
1Department of Immunology, Maragheh Faculty: Tabriz university of medical sciences, Tabriz, Iran.
2Department of Biochemistry, Maragheh Faculty: Tabriz university of medical sciences, Tabriz, Iran.
3Educational assistant of Maragheh Faculty: Tabriz university of medical sciences, Tabriz, Iran
*Corresponding author
  Received : April 26, 2012
  Revised : May 14, 2012
  Accepted : May 27, 2012
  Published : May 28, 2012
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Background: Serum concentration of cystatin C a marker of glomerular filtration has been associated with cardiovascular disease (CVD). The aim of this study was To evaluate cystatin C as a marker of obese patients without chronic kidney disease (CKD).
Materials and Methods: The study population consisted of 36 subjects with metabolic syndrome and 32 subjects free of metabolic syndrome (control group). HDL-C, LDL-C, blood urea, triglycerides, glucose, HbA1c, serum cystatin C and serum creatinine were measured in both groups. GFR was calculated in both groups using Cockroft밎ault equation.
Results: Obese patients presented higher cystatin C levels than normal samples (1.28 짹0.29, p<0.05). In the binary logistic regression, the presence of Obese patients was significantly associated with elevated cystatin C levels.
Conclusion: Our results suggests that cystatin C may be a marker for Obese patients and may identify a certain degree of renal dysfunction even when serum creatinine does not exceed normal level. In this study we demonstrated that serum creatinineand GFR did not differ significantly between diabetic and control group serum concentration of cystatin C was significantly higher in diabetic group compared with control group. The strengths of this study are the evaluation of reliability, and sensivity incomparison with a 쁱outine test of GFR in an adequately study. The methodology used allows appropriate statistical comparisons of reliabilityin contrast to most other previous evaluations of GFR.

Keyword: serum cystatin c, renal dysfunction, obesity, nephropaty, specifity
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