Interdisciplinary Bio Central
 
Essay (Bioinformatics/Computational biology/Molecular modeling)

Development of Information Biology (III)
Yoshio Tateno1,*
1Daegu Gyeongbuk Institute of Science and Technology, Dalseong, Daegu, 711-873, Republic of Korea
*Corresponding author
  Received : June 13, 2013
  Accepted : June 27, 2013
  Published : June 28, 2013
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Synopsis

Introduced were two biological investigations in which information biology played a significant role. In the first case independent findings in cancer research over a long period were united and organized by information biology and led to the outcome that was subject to a Nobel Prize. The outcome has revealed that the cause of human cancer is located in the genome in a dormant condition. The second case shows how to elucidate the function of an unknown DNA sequence or ORF in prokaryotes by a large scale computer homology search and analyses. For the elucidation the International DNA Databases and a large scale computer were two key factors.

Keyword: Oncogene, Proto-oncogene, PDGF, ORF, computer homology analysis
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