Interdisciplinary Bio Central
 
Etc. (Bioinformatics/Computational biology/Molecular modeling)

Inference of Genetic Regulatory Modules Using ChIP-on-chip and mRNA Expression Data
Hyeyoung Cho1 and Doheon Lee1,*
1Department of Bio and Brain Engineering, KAIST
*Corresponding author
  Published : May 31, 2007
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Synopsis

We present here the strategy of data integration for inference of genetic regulatory modules. First, we construct all possible combinations of regulators of genes using chromatin-immunoprecipitation(ChIP)-chip data. Second, hierarchical clustering method is employed to analyze mRNA expression profiles. Third, integration method is applied to both of the data. Finally, we construct a genetic regulatory module which is involved in the function of ribosomal protein synthesis.

Keyword: Genetic Regulatory Modules, ChIP-chip, mRNA expression profiles
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