Interdisciplinary Bio Central
 
Etc. (Bioimaging)

In Vivo Reporter Gene Imaging: Recent Progress of PET and Optical Imaging Approaches
Jung-Joon Min1,2,*
1Department Nuclear Medicine, Chonnam National University Medical School, Gwangju, Korea
2Laboratory of In Vivo Molecular Imaging, Institute for Molecular Photonic Imaging Research, Chonnam National University Hwasun Hospital, Hwasun, Jeonnam, Korea
*Corresponding author
  Published : February 28, 2006
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Synopsis

Recent progress in the development of non-invasive imaging technologies continues to strengthen the role of molecular imaging biological research. These tools have been validated recently in variety of research models, and have been shown to provide continuous quantitative monitoring of the location(s), magnitude, and time-variation of gene delivery and/or expression. This article reviews the use of radionuclide, magnetic resonance, and optical imaging technologies as they have been used in imaging gene delivery and gene expression for molecular imaging applications. The studies published to date demonstrate that noninvasive imaging tools will help to accelerate pre-clinical model validation as well as allow for clinical monitoring of human diseases.

Keyword: Molecular imaging, Positron Emission Tomography, Magnetic Resonance Imaging, Optical Imaging, Reporter gene, Gene expression,
IBC   ISSN : 2005-8543   Contact IBC